• ul. Postępu 36A, Jastrzębiec

    05-552 Magdalenka, Polska

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    tel. +48 22 736-70-00
    fax +48 22 756-16-99

  • slidebg1
    INPEX 2016
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    Brussels Innova

DEPARTMENT OF MOLECULAR BIOLOGY

PLANS FOR THE FUTURE

The following studies will be carried in the nearby future:

  • Use of functional genomics in animal production: application of transcriptomics, epigenomics, proteomics in studying expression of bovine genes determining meat production, beef quality, yield and composition of cows’ milk.
  • Analysis of expression profiles of genes encoding regulatory proteins and regulatory RNAs (miRNA), methylation of gene regulatory regions in skeletal muscles, mammary gland, and other organs and tissues of cattle; construction of gene expression and regulation networks.
  • Application of large-scale techniques of functional genomics (expression, methylation and SNP microarrays, next generation sequencing, bioinformatics, and system biology) to study aimed at comprehensive understanding the physiology of farm animals. Studies of the regulation of gene expression in cattle on the whole-genome level.
  • Continuation of the studies of functional polymorphisms of candidate genes to identify molecular markers for animal breeding and animal production.
  • Metagenomic analysis of rumen and gut microbiome profile of the livestock with the use of next-generation sequencing technology (NGS).
  • Application of new molecular approach in the field of nutrigenomics  - next generation sequencing (NGS), including whole mRNA transcriptome sequencing and transcript profiling of microRNAs.
  • Genome engineering using designer nuclease technologies (CRISPR/Cas) of induced pluripotent stem cells (iPSC) to study central nervous system disease mechanisms by reverse genetics.
  • Studies of gene expression and gene regulation in brain of mice submitted to chronic stress, in relation to mood disorders and neurodegenerative diseases.
  • Use of heme iron preparations and iron nanoparticles in preventing iron deficiency anemia in newborn piglets and iron deficient mice.
  • Interactions between non-heme and heme iron metabolisms – studies on mice with knockout of Hmox1 gene (encoding heme oxygenase 1).
  • Regulation of cellular and systemic iron metabolism by nitric oxide (NO) in normoxia and hypoxia.
  • Studies of iron metabolism in mice with knockout of Atp7a and Atp7b genes – mouse models of Menkes and Wilson diseases, respectively.
  • Role of growth differentiation factor 15 (GDF15) and erythroferrone in the regulation of iron metabolism in pregnancy under iron deficiency
  • Role of iron metabolism misregulation in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Studies on mice carrying the human mutation in the Cu/Zn superoxide dismutase 1 (SOD1) gene (SOD1G93A).
  • Characterisation of bioeffects of palnt constituents pesent in medicinal plants or food sources.