Assistant profesor, Head of Laboratory of Iron Molecular Biology
Field of interest
Molecular regulation of heme/nonheme iron and copper metabolisms in mammals. Influence of oxidative stress and nitric oxide on cellular and systemic iron metabolism.
Author of app. 50 research articles including 37 articles in journals from the JCR list. Author of 2 chapters in books. Citations app. 480, IH=12
Selected scientific achievements
Initiation in Poland of regular studies on iron metabolism in mammals and co-initiation (together with dr Małgorzata Lenartowicz from Jagiellonian University) of studies on the interaction between copper and iron metabolisms. The latter have been awarded by the Divison of Biological and Agricultural Sciences of the Polish Academy of Sciences in 2011.
Demonstration that high/low level of labile iron pool established as a consequence of differentiated regulation of intracellular iron homeostasis in the two sublines of mouse lymphoblasts is the main cause of their sensitivity/resistance to hydrogen peroxide (H2O2) These results provide a paradigm of the relationship between the regulation of intracellular iron homeostasis and mammalian cell sensitivity to oxidative stress.
Demonstration that IRP1 is critically important for the regulation of cellular iron transport andstorage by NO and uncovers aspects of iron metabolism that cannot be compensated byIRP2
Identification of molecular pathways and mechanisms of heme iron absorption in pig duodenum. Determination of innovative procedures of the correction of iron deficiency anemia in newborn piglets.
Realized research projects
Supervisor research grant founded by Leading National Research Center, Scientific Consortium „Healthy Animal-safe food” (2016-2019)
Identification of molecular mechanisms of interaction between copper and iron metabolisms and use of copper for the treatment of iron deficiency anemia in piglets
Project realized in the frame of the Indian-Polish Inter-Governmental Science & Technology Cooperation Programme (2015-2017)
Role of growth differentiation factor 15 (GDF15) in the regulation of iron metabolism in pregnancy under iron deficiency”
The National Science Centre grant (2011-2014)
Downregulation of Iron Regulatory Protein 1 expression in oxidative stress: molecular mechanisms, impact on intracellular iron metabolism, importance in the pathogenesis of Amyotropic Lateral Sclerosis.
NCN OPUS, 2020- 2023
Molecular mechanisms of transplacental iron transport and regulation of iron metabolism in domestic pig and wild boar neonates: comparative studies
Organizational activity, dissemination and others
Founder of the Polish Iron Club (PIC) and main organizer of successive Meetings of the Polish Iron Club (Jastrzębiec 2010 and 2015, Gdańsk 2017). Organizer and chairman of the “Iron Session” during the 2nd Polish Congress of Biochemistry and Cell Biology, Cracow, September 5-9. Initiator and coordinator of the two cycles of articles on iron metabolism published in BioTechnologia (2011) and Kosmos (Tales of iron, 2014).
Selected publications and patents
Staroń R, LIPIŃSKI P, Lenartowicz M, Bednarz A, Gajowiak A, Smuda E, Krzeptowski W, Pieszka M, Korolonek T, Hamza I, Swinkels DW, Van Swelm RPL, Starzyński RR. (2017) Dietary hemoglobin rescues young piglets from severe iron deficiency anemia: Duodenal expression profile of genes involved in heme iron absorption. PLoS One 12(7):e0181117.
Styś A, Galy B, Starzyński RR, Smuda E, Drapier J-C, LIPIŃSKI P, Bouton C. (2011) Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide. Journal of Biological Chemistry 286(26):22846-54.
LIPIŃSKI P, Starzyński RR, Canonne-Hergaux F, Tudek B, Oliński R, Kowalczyk P, Dziaman T, Thibaudeau O, Gralak MA, Smuda E, Woliński J, Usińska A, Zabielski R. (2010) Benefits and risks of iron supplementation in anemic neonatal pigs. American Journal of Pathology 177(3):1233-1243.
Starzyński RR, LIPIŃSKI P, Drapier JC, Diet A, Smuda E, Bartlomiejczyk T, Gralak MA, Kruszewski M. (2005) Down-regulation of iron regulatory protein 1 activities and expression in superoxide dismutase 1 knock-out mice is not associated with alterations in iron metabolism. Journal of Biological Chemistry 280(6):4207-4212.
LIPIŃSKI P, Drapier J-C, Oliveira L, Retmańska H, Sochanowicz B, Kruszewski M. (2000) Intracellular iron status as a hallmark of mammalian cell susceptibility to oxidative stress: a study of L5178Y mouse lymphoma cell lines differentially sensitive to H2O2. Blood 95(9):2960-2966.